Go to NVIDIA control panel - I can do this by right clicking on the icon in my tray and selecting 'NVIDIA Control Panel', but you can also: Instructions are in other answers and in the wikihow article that I adapted the NVIDIA instructions from If you don't have an NVIDIA card, then as others have said you can use the Accessibility High Contrast features to approximate inverted colors and the magnifier glass gives some functionality on XP, but I found this unsatisfying (and I have to use XP for work). I use this successfully with my work computer. The following won't work for everyone, but if you have XP and an NVIDIA graphics card then there is a proper color inversion that is equivalent to the Mac.
